GC/MS can handle mixtures. The GC effluent is directed into the mass spectrometer, where a spectrum of each component is obtained as it elutes from the column. Just as an FID gives a response based on the number of ions formed as sample elutes from the column, so does GC/MS, in the form of a total ion chromatogram (TIC). 

Coupling HPLC with mass spectrometry allows analysis of mixture samples. It can provide information on individual compounds even when present in complex mixtures, including identification by molecular weight, structure characterization through fragmentation, and quantitation. Obviously, it provides more specific information about a compound than optical detectors.

MS/MS is not an ionization technique but a method for structure determination and analysis of molecules. Traditionally, MS/MS uses two mass spectrometers in tandem. Between the two analyzers (MS1 and MS2) is a collision gas cell. Precursor ions selected by MS1 collide with a high pressure gas (usually He) in the cell and undergo fragmentation. The resulting daughter ions are analyzed in MS2. The collision process is called collision induced dissociation (CID). In the Synapt G2 Si and QTof, the collision cell is located between the quadrupole and TOF analyzers.

Tracking Student Usage of MS used and number of samples run.

Instruments available:

Bruker Autoflex Speed LRF MALDI
Bruker Daltonics UltrafleXtreme MALDI TOFTOF
Waters Q-TOF Ultima ESI
Waters GCT Premier EI/CI/FD/FI
Waters Quattro Ultima ESI
Waters Synapt G2-Si ESI/LC-MS (2014)
Waters Synapt G2-Si ESI/LC-MS (2020)
Waters ZMD Quadrupole Instrument